Why Intra-Tumoral Chlorine Dioxide Injection Is Safer Than Traditional Ablation and Biopsy Techniques

An Alternative Perspective on Needle Size, Risk, and the Future of Low-Trauma Cancer Treatment

In recent years, multiple technologies have been developed to treat solid tumors through localized interventions. Among them, radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation, and irreversible electroporation (IRE) have gained wide attention. Yet one critical aspect is often overlooked: the size of the needle and the associated risks, especially bleeding, tissue trauma, and metastatic spread.

As the inventor of Intra-Tumoral Chlorine Dioxide (ClO₂) Injection Therapy, I believe it is time to shed light on the understated advantages of our method compared to these mainstream ablative techniques and even conventional biopsy procedures.

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Needle Size: The Root of Risk

Let us begin by examining the size of needles typically used in different procedures:

• Cryoablation: 14G–16G

• Microwave Ablation: 16G–17G

• IRE (Electroporation): 16G–19G

• Core Needle Biopsy: 16G–18G

• Fine Needle Aspiration Biopsy: 22G–23G

• ClO₂ Injection (Our Method): 23G–25G

These numbers matter. A smaller gauge number means a thicker needle. Most ablative techniques use large-bore needles to deliver energy or cryogens effectively. But this increases the risk of:

• Bleeding, especially in vascular organs like the liver or lungs

• Infection

• Tissue trauma, which delays healing

• Cancer cell seeding, particularly after biopsy

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Why ClO₂ Injection Is Safer

1. Minimally Invasive
   – We use extremely fine needles (23G–25G), thinner than those used in most biopsies. This minimizes bleeding and post-procedure pain.

2. No Tissue Destruction
   – Unlike ablation, which burns or freezes tissue (causing collateral damage), ClO₂ selectively kills tumor cells through redox-based mechanisms, sparing nearby healthy tissue.

3. Outpatient Feasibility
   – The injection takes seconds. Most patients can walk out immediately after, without hospitalization or anesthesia.

4. Anti-Metastasis Effect
   – Here lies the most overlooked but revolutionary feature: ClO₂’s chemical properties allow it to oxidize and neutralize cancer cells that might be dislodged along the needle track. This means even if a few cells escape during needle withdrawal, they are likely to be destroyed by residual ClO₂.

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Biopsy vs. Treatment

It is ironic that patients are often advised to undergo core needle biopsies — using 16G–18G needles — for diagnosis, while ClO₂ therapy, which uses finer needles and has the potential to treat the disease, is viewed with hesitation. In fact, many patients and clinicians have voiced concerns that biopsy itself may cause tumor spread.

Our therapy is not just less invasive than biopsy — it is also safer.

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Conclusion

Needle size is not a trivial detail. It defines safety. With Intra-Tumoral ClO₂ Injection Therapy, we offer a path that avoids the mechanical trauma, systemic toxicity, and procedural risks associated with traditional ablative techniques. Moreover, the added benefit of neutralizing dislodged cancer cells makes our approach not just safe, but elegantly protective.

As more patients seek gentler, effective alternatives, ClO₂ injection offers a future where cancer treatment is no longer synonymous with collateral damage.

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