Rapid Local Necrosis After a Single High-Dose ClO₂ Injection in a Patient with NUT Midline Carcinoma (NUT carcinoma)
⚠️ [Tumor Image Warning – Viewer Discretion Advised]
Today, we present a documented case from China involving a patient diagnosed with aggressive NUT midline carcinoma (NUT carcinoma) presenting as a large cervical mass, who received a high-concentration intratumoral injection of chlorine dioxide (ClO₂).
⚠️ This article contains real tumor photographs (pre- and post-injection). Viewer discretion is advised.
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What Is NUT Midline Carcinoma (NUT Carcinoma)?
NUT carcinoma is a rare, highly aggressive cancer defined by a genetic rearrangement involving the NUTM1 gene—most commonly a BRD4–NUTM1 fusion. It typically arises along the midline structures of the body, including the head and neck (especially the nasopharynx), mediastinum, and occasionally other soft tissue or visceral sites. Most patients present at an advanced stage, and the disease progresses rapidly.
Conventional treatment approaches such as chemotherapy and radiotherapy often provide limited benefit, and the median survival is less than one year. Due to its rarity and aggressive nature, NUT carcinoma is frequently misdiagnosed or only identified after rapid progression.
Accurate diagnosis requires genetic or immunohistochemical testing (e.g., NUT-specific staining or NGS analysis). There are currently no FDA-approved targeted therapies, although BET inhibitors are being explored in clinical trials.
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Treatment Context
Patient: Diagnosed with advanced-stage NUT carcinoma, presenting as a large infiltrative lymphatic tumor in the midline neck region.
Injection Site: A bulky, deeply infiltrated mass consistent with aggressive midline disease.
Dose: 10 mL of high-concentration chlorine dioxide solution.
Local Anesthesia: 10 mL of lidocaine was used for infiltration.
Procedure Note: Due to limited clinical setup, no intravenous sedation was available, and the patient experienced intense pain during the injection.
Injection Performed by: A local physician unfamiliar with the standard ClO₂ intratumoral protocol, but followed basic instructions.
Time between images: ~12 hours.
📸 Pre- and Post-Injection Image Comparison (12 hours apart)
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Image 1: Before Injection
The tumor mass is highly raised, irregular, multi-lobulated, and covered with stretched skin showing signs of chronic inflammation.
No clear signs of central necrosis.
Skin surface appears thickened and partially crusted, but with no blackened core.
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Image 2: 12 Hours After Injection
A central necrotic core has appeared (highlighted in red), showing dark black-brown discoloration indicative of coagulative necrosis.
Localized tissue collapse is evident, with decreased tension in the central area.
No active bleeding, ulceration, or rupture of the overlying skin.
Surrounding skin shows a darkened hue, likely caused by oxidative metabolites diffusing into the peritumoral lymphatic tissues, but not suggestive of deep tissue injury.
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Effectiveness Analysis
Despite the following limitations:
No ultrasound or CT guidance
No sedation for pain control
Only one injection performed
Operator not yet experienced
…the result is remarkably positive. Within just 12 hours, the injected tumor region developed a clear necrotic core, suggesting that:
Chlorine dioxide has initiated rapid tumor devitalization through direct oxidative destruction and microvascular shutdown, even in a large, advanced lymph node tumor.
This confirms our hypothesis that even a single injection, when correctly placed, can initiate the necrotic cascade leading to tumor reduction.
🔬 Clinical Interpretation
Observation
Interpretation
Central blackened core
Successful coagulative necrosis
Skin intact, no bleeding
Safe injection depth and volume
Surrounding discoloration
Likely non-injurious oxidative diffusion
Visible tissue collapse
Early tumor volume reduction
🧠 Reflections & Next Steps
This case reinforces several important insights:
Even inexperienced physicians can initiate effective tumor necrosis, if basic injection protocols are followed.
Pain control is critical — IV sedation should be standard in large or sensitive tumors.
A single high-dose ClO₂ injection can produce visible effects within 8–12 hours, especially in soft tissue tumors.
This method may become a low-cost, low-tech, and high-impact solution for resource-limited settings — especially for palliative or non-operable cases.
📸 Below:
Top image — before injection
Bottom image — 12 hours after injection (red circle indicates next planned injection site)
(👉 You may now scroll to view the images)
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That is a huge mass. How would you know where to inject, to reach the correct place and what is the correct place? The patient was brave with limited pain relief and so was the doctor administering the dose. I should imagine the different camera angle was used to better highlight the start of the deterioration of the tumour. Will he need repeat injections? I hope his treatment is successful and we see followups. Is this cancer only on his neck still or has it spread? Asking as tumour so large. Obviously I'm hoping not and wanting 100% success.
Now I’m left wondering if this would work for all of the ppl who have developed cancers after taking the quackzines